What is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium — NNMT inhibitor) is a Small molecule (C₁₀H₁₀N₂, MW 174.2). Competitive NNMT (nicotinamide N-methyltransferase) inhibitor preventing nicotinamide from being diverted away from the NAD+ salvage pathway. Preserves SAM methyl donor pool and improves SAM/SAH ratio for epigenetic methylation. Indirect NAD+ increase → SIRT1 activation → PGC-1α → mitochondrial biogenesis.
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