GHK-Cu (Glycyl-L-histidyl-L-lysine copper(II) complex) is a Copper-binding tripeptide. Naturally occurring copper tripeptide that activates fibroblasts to upregulate collagen I/III/IV and elastin synthesis, inhibits MMP-1/2/9 collagen degradation enzymes, activates lysyl oxidase for collagen cross-linking, stimulates wound bed angiogenesis via VEGF/FGF-2, and activates Nrf2 antioxidant response element genes. Plasma concentration declines ~60% with ageing.

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